Methylenetetrahydrofolate Reductase C677T Polymorphism and Cervical Cancer Risk: a Meta-Analysis
نویسندگان
چکیده
منابع مشابه
Methylenetetrahydrofolate Reductase C677T Polymorphism and Susceptibility to Cervical Cancer and Cervical Intraepithelial Neoplasia: A Meta-Analysis
BACKGROUND A number of studies have explored the association between methyl enetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to cervical cancer and cervical intraepithelial neoplasia (CIN). However, results remained controversial. To address this gap, we decided to conduct a meta-analysis of all available published studies. METHODS Electronic literature searches of ...
متن کاملAssociation between Methylenetetrahydrofolate Reductase C677T Polymorphism and Susceptibility to Cervical Cancer: A Meta-Analysis
BACKGROUND To assess the association between MTHFR polymorphism and cervical cancer risk, a meta-analysis was performed. METHODS Based on comprehensive searches of the PubMed, Embase, and Web of Science databases, we identified outcome data from all articles estimating the association between MTHFR polymorphism and cervical cancer risk. The pooled odds ratio (OR) with 95% confidence intervals...
متن کاملMTHFR C677T Polymorphism and Cervical Cancer Risk: a Meta-Analysis
Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in the females worldwide, accounting for 9% (529,800 cases) of the total new cancer cases and 8% (275,100 deaths) of the total cancer deaths among females in 2008 (Jemal et al., 2011). More than 85% of these cases and deaths occur in developing countries (Jemal et al., 2011, Li et al., 2011)...
متن کاملAssociation between the methylenetetrahydrofolate reductase C677T polymorphism and hepatocellular carcinoma risk: a meta-analysis
BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate. The non-synonymous single nucleotide polymorphism (nsSNP), C677T (Ala>Val, rs1801133), has been verified to impair enzyme activity. The association with cancer susceptibility, including hepatocellular carcinoma (HCC), has also been widely studied. The results, however, were inconsistent. To shed ...
متن کاملMaternal Methylenetetrahydrofolate Reductase C677T Polymorphism and Down Syndrome Risk: A Meta-Analysis from 34 Studies
BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolic pathway which catalyzes the irreversible conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate donates methyl group for the methylation of homocysteine to methionine. Several studies have investigated maternal MTHFR C677T polymorphism as a risk factor for DS, ...
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Cancer Prevention
سال: 2012
ISSN: 1513-7368
DOI: 10.7314/apjcp.2012.13.5.2193